How was the SCPP gene family formed?

During the evolution of jawed vertebrates, SPARCL1
expanded through a series of gene duplications to create
the SCPP gene family. The repertoire of SCPP genes varies
greatly among vertebrates. In humans, there are 22
SCPP genes arranged in two clusters on chromosome
4, in addition to the amelogenin genes (AMELX and
AMELY) on the X and Y chromosomes. The two chromosome
4 SCPP clusters separated early in vertebrate evolution
and diverged into two classes of extracellular matrix
proteins. The dentin/bone SCPPs form the smaller, older
cluster, and include DSPP , DMP1 , IBSP , MEPE , and SPP1 ,
which arose from a common ancestor by tandem gene
duplication and have been designated the small integrinbinding
ligand, N-linked glycoproteins, or SIBLINGs.
The larger, more recent cluster of SCPPs contains the
genes encoding the enamel proteins, caseins and some
salivary proteins.

Table of SCPP Genes and Ancestors

Sources:

Molecular Evolution and Genetic Defects of Teeth, Cells Tissues Organs, 2007

Formation of the SCPP (secretory calcium-binding phosphoprotein) gene family

How was the SCPP gene family formed?

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