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How are dental root variants affected by genetic factors
Defects in the transcription factor gene DLX3 were
previously shown to cause the tricho-dento-osseous syndrome,
and it has been suggested that some DLX3 mutations
might cause AI hypoplastic-hypomaturation with
taurodontism. Wright (University of North Carolina), in
The Molecular Control of and Clinical Variations in Root
Formation, clarifies the role of DLX3 in the etiology of
tooth defects as he reviews our understanding of developmental
defects of root formation, the molecular mechanisms
involved, and the impact of root variants on clinical
dentistry.
Sources:
- Molecular Evolution and Genetic Defects of Teeth, Cells Tissues Organs, 2007
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