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What are some problems in the crown formation stage of dental development
During the crown formation stage, odontoblasts and
ameloblasts act in concert to orchestrate the extracellular
deposition of dentin and enamel. P. Suzanne and Thomas
C. Hart (National Institutes of Health), in Disorders of
Human Dentin, summarize the current classification
system for inherited defects in dentin, which includes
three types of dentinogenesis imperfecta (DI) and two
types of dentin dysplasia (DD). It has long been known
that defects in the genes encoding type I collagen are responsible
for DI-I, which is the syndromic form of DI-II.
Sources:
- Molecular Evolution and Genetic Defects of Teeth, Cells Tissues Organs, 2007
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