What contributes to non-syndromic dentin defects

The recent genetic breakthroughs concerning non-syndromic
dentin defects relate to the single-handed importance
of DSPP (dentin sialophosphoprotein). This SCPP
gene has now been implicated in the etiologies of DD-II,
DI-II, and DI-III, which appear to be successively more
severe forms of DSPP defects. Defects in another SCPP
gene, DMP1 (dentin matrix acidic phosphoprotein), cause
autosomal recessive hypophosphatemia, and (surprisingly)
are not part of the etiology of isolated dentin defects.
Implication of DMP1 in the regulation of phosphate homeostasis
suggests that vertebrate biomineralization
evolved in tandem with mechanisms to regulate phosphate,
and probably calcium homeostasis.

Sources:

Molecular Evolution and Genetic Defects of Teeth, Cells Tissues Organs, 2007

What causes non-syndromic dentin defects in teeth

What contributes to non-syndromic dentin defects